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1

Systems vaccinology and big data in the vaccine development chain

Raeven, René H. M., van Riet, Elly, Meiring, Hugo D., Metz, Bernard, Kersten, Gideon F. A.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.35 MB

english, 2018

2

Towards tailored vaccine delivery: Needs, challenges and perspectives

Jean-Pierre Amorij, Gideon F.A. Kersten, Vinay Saluja, Wouter F. Tonnis, Wouter L.J. Hinrichs, Bram Slütter, Suzanne M. Bal, Joke A. Bouwstra, Anke Huckriede, Wim Jiskoot

Journal:

Journal of Controlled Release

Year:

2012

Language:

english

File:

PDF, 514 KB

english, 2012

3

Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines

Bernard Metz, Wim Jiskoot, Wim E Hennink, Daan J.A Crommelin, Gideon F.A Kersten

Journal:

Year:

2003

Language:

english

File:

PDF, 325 KB

english, 2003

4

Hepatitis B surface antigen nanoparticles coated with chitosan and trimethyl chitosan: Impact of formulation on physicochemical and immunological characteristics

Mohsen Tafaghodi, Vinay Saluja, Gideon F.A. Kersten, Heleen Kraan, Bram Slütter, Jean-Pierre Amorij, Wim Jiskoot

Journal:

Year:

2012

Language:

english

File:

PDF, 687 KB

english, 2012

5

Antigen delivery systems

Kersten, Gideon, Hirschberg, Hoang

Journal:

Expert Review of Vaccines

Year:

2004

Language:

english

File:

PDF, 120 KB

english, 2004

6

Combatting infectious diseases; nanotechnology as a platform for rational vaccine design

van Riet, Elly, Ainai, Akira, Suzuki, Tadaki, Kersten, Gideon, Hasegawa, Hideki

Journal:

Advanced Drug Delivery Reviews

Year:

2014

Language:

english

File:

PDF, 349 KB

english, 2014

7

Predicting the influence of liposomal lipid composition on liposome size, zeta potential and liposome-induced dendritic cell maturation using a design of experiments approach

Soema, Peter C., Willems, Geert-Jan, Jiskoot, Wim, Amorij, Jean-Pierre, Kersten, Gideon F.

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2015

Language:

english

File:

PDF, 652 KB

english, 2015

8

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles

Schipper, Pim, van der Maaden, Koen, Romeijn, Stefan, Oomens, Cees, Kersten, Gideon, Jiskoot, Wim, Bouwstra, Joke

Journal:

Pharmaceutical Research

Year:

2016

Language:

english

File:

PDF, 956 KB

english, 2016

9

Influenza Vaccine Manufacturing: Effect of Inactivation, Splitting and Site of Manufacturing. Comparison of Influenza Vaccine Production Processes

Kon, Theone C., Onu, Adrian, Berbecila, Laurentiu, Lupulescu, Emilia, Ghiorgisor, Alina, Kersten, Gideon F., Cui, Yi-Qing, Amorij, Jean-Pierre, Van der Pol, Leo, Krammer, Florian

Journal:

Year:

2016

Language:

english

File:

PDF, 2.83 MB

english, 2016

10

Vaccine antigens modulate the innate response of monocytes to Al(OH)3

Kooijman, Sietske, Brummelman, Jolanda, van Els, Cécile A. C. M., Marino, Fabio, Heck, Albert J. R., van Riet, Elly, Metz, Bernard, Kersten, Gideon F. A., Pennings, Jeroen L. A., Meiring, Hugo D., Ban

Journal:

Year:

2018

Language:

english

File:

PDF, 4.15 MB

english, 2018

11

Development of Cross-Protective Influenza A Vaccines Based on Cellular Responses

Soema, Peter Christiaan, van Riet, Elly, Kersten, Gideon, Amorij, Jean-Pierre

Journal:

Frontiers in Immunology

Year:

2015

Language:

english

File:

PDF, 428 KB

english, 2015

12

Hyaluronan-based dissolving microneedles with high antigen content for intradermal vaccination: formulation, physicochemical characterization and immunogenicity assessment

Leone, Mara, Priester, Marjolein I., Romeijn, Stefan, Reza Nejadnik, M., Mönkäre, Juha, O'Mahony, Conor, Jiskoot, Wim, Kersten, Gideon, Bouwstra, Joke A.

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2018

File:

PDF, 1.94 MB

2018

13

Hyaluronan molecular weight: Effects on dissolution time of dissolving microneedles in the skin and on immunogenicity of antigen

Leone, Mara, Romeijn, Stefan, SlÃ¼tter, Bram, OâMahony, Conor, Kersten, Gideon, Bouwstra, Joke A.

Journal:

European Journal of Pharmaceutical Sciences

Year:

2020

File:

PDF, 1.10 MB

2020

14

Intranasal immunization with outer membrane vesicle pertussis vaccine confers broad protection through mucosal IgA and Th17 responses

Raeven, RenÃ© H. M., Rockx-Brouwer, Dedeke, Kanojia, Gaurav, van der Maas, Larissa, Bindels, Tim H. E., ten Have, Rimko, van Riet, Elly, Metz, Bernard, Kersten, Gideon F. A.

Journal:

Scientific Reports

Year:

2020

File:

PDF, 2.17 MB

2020

15

Glycosyl compositions and structural characteristics of the potential immuno-adjuvant active saponins in the Quillaja saponaria Molina extract Quil A

Dirk C. van Setten, Gerrit van de Werken, Gijsbert Zomer, Gideon F. A. Kersten

Journal:

Rapid Communications in Mass Spectrometry

Year:

1995

Language:

english

File:

PDF, 613 KB

english, 1995

16

Transcutaneous Immunization Studies in Mice Using Diphtheria Toxoid-Loaded Vesicle Formulations and a Microneedle Array

Zhi Ding, Suzanne M. Bal, Stefan Romeijn, Gideon F. A. Kersten, Wim Jiskoot, Joke A. Bouwstra

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 310 KB

english, 2011

17

Microneedle-Based Transcutaneous Immunisation in Mice with N-Trimethyl Chitosan Adjuvanted Diphtheria Toxoid Formulations

Suzanne M. Bal, Zhi Ding, Gideon F. A. Kersten, Wim Jiskoot, Joke A. Bouwstra

Journal:

Pharmaceutical Research

Year:

2010

Language:

english

File:

PDF, 570 KB

english, 2010

18

Liposomes and ISCOMS as vaccine formulations

Gideon F.A. Kersten, Daan J.A. Crommelin

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes

Year:

1995

Language:

english

File:

PDF, 2.17 MB

english, 1995

19

Technology transfer of Sabin-IPV to new developing country markets

Hans Kreeftenberg, Tiny van der Velden, Gideon Kersten, Nico van der Heuvel, Marloes de Bruijn

Journal:

Year:

2006

Language:

english

File:

PDF, 112 KB

english, 2006

20

Immunogenicity of meningococcal PorA formulations encapsulated in biodegradable microspheres

Carmen Arigita, Joost van den Berg, Karin Wensink, Mies van Steenbergen, Wim E Hennink, Daan J.A Crommelin, Gideon F.A Kersten, Wim Jiskoot

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 192 KB

english, 2004

21

Virosome and ISCOM vaccines against Newcastle disease: preparation, characterization and immunogenicity

Atthachai Homhuan, Sompol Prakongpan, Prachak Poomvises, Riks A Maas, Daan J.A Crommelin, Gideon F.A Kersten, Wim Jiskoot

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 203 KB

english, 2004

22

A combined approach of vesicle formulations and microneedle arrays for transcutaneous immunization against hepatitis B virus

Hoang Hirschberg, Sandra van Kuijk, Jessica Loch, Wim Jiskoot, Joke Bouwstra, Gideon Kersten, Jean-Pierre Amorij

Journal:

European Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 498 KB

english, 2012

23

Efficient induction of immune responses through intradermal vaccination with N-trimethyl chitosan containing antigen formulations

Suzanne M. Bal, Bram Slütter, Elly van Riet, Annelieke C. Kruithof, Zhi Ding, Gideon F.A. Kersten, Wim Jiskoot, Joke A. Bouwstra

Journal:

Journal of Controlled Release

Year:

2010

Language:

english

File:

PDF, 905 KB

english, 2010

24

Bioneedles as alternative delivery system for hepatitis B vaccine

Hoang J.H.B. Hirschberg, Gijsbert G.P. van de Wijdeven, Heleen Kraan, Jean-Pierre Amorij, Gideon F.A. Kersten

Journal:

Journal of Controlled Release

Year:

2010

Language:

english

File:

PDF, 1.01 MB

english, 2010

25

Comparison of 24 different adjuvants for inactivated HIV-2 split whole virus as antigen in mice. Induction of titres of binding antibodies and toxicity of the formulations

Frank Stieneker, Gideon Kersten, Louis van Bloois, Daan J.A. Crommelin, Stanley L. Hem, Johannes Löwer, Jörg Kreuter

Journal:

Year:

1995

Language:

english

File:

PDF, 1.37 MB

english, 1995

26

On the structure of immune-stimulating saponin-lipid complexes (iscoms)

Gideon F.A. Kersten, Arjen Spiekstra, E. Coen Beuvery, Daan J.A. Crommelin

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1991

Language:

english

File:

PDF, 2.01 MB

english, 1991

27

Stability of mono- and trivalent meningococcal outer membrane vesicle vaccines

Carmen Arigita, Wim Jiskoot, Janny Westdijk, Cor van Ingen, Wim E. Hennink, Daan J.A. Crommelin, Gideon F.A. Kersten

Journal:

Year:

2004

Language:

english

File:

PDF, 425 KB

english, 2004

28

Well-defined and potent liposomal meningococcal B vaccines adjuvated with LPS derivatives

Carmen Arigita, Thomas Luijkx, Wim Jiskoot, Martien Poelen, Wim E. Hennink, Daan J.A. Crommelin, Peter van der Ley, Cecile van Els, Gideon F.A. Kersten

Journal:

Year:

2005

Language:

english

File:

PDF, 270 KB

english, 2005

29

Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: Preparation, characterization and evaluation in guinea pigs

Maryam Amidi, Hubert C. Pellikaan, Hoang Hirschberg, Anne H. de Boer, Daan J.A. Crommelin, Wim E. Hennink, Gideon Kersten, Wim Jiskoot

Journal:

Year:

2007

Language:

english

File:

PDF, 716 KB

english, 2007

30

Quality control of routine, experimental and real-time aged diphtheria toxoids by in vitro analytical techniques

Bernard Metz, Wim Jiskoot, Dirk Mekkes, Robert Kingma, Wim E. Hennink, Daan J.A. Crommelin, Gideon F.A. Kersten

Journal:

Year:

2007

Language:

english

File:

PDF, 586 KB

english, 2007

31

Bioneedles™ as vaccine carriers

Hoang J.H.B. Hirschberg, Gijsbert G.P. van de Wijdeven, Annemarie B. Kelder, Germie P.J.M. van den Dobbelsteen, Gideon F.A. Kersten

Journal:

Year:

2008

Language:

english

File:

PDF, 1.09 MB

english, 2008

32

Characterization and standardization of Sabin based inactivated polio vaccine: Proposal for a new antigen unit for inactivated polio vaccines

Janny Westdijk, Debbie Brugmans, Javier Martin, Aart van’t Oever, Wilfried A.M. Bakker, Lonneke Levels, Gideon Kersten

Journal:

Year:

2011

Language:

english

File:

PDF, 777 KB

english, 2011

33

In vivo antibody response and in vitro CTL activation induced by selected measles vaccine candidates, prepared with purified Quil A components

Koert J Stittelaar, Jolande Boes, Gideon F.A Kersten, Arjen Spiekstra, Paul G.H Mulder, Petra de Vries, Paul J.M Roholl, Kristian Dalsgaard, Germie van den Dobbelsteen, Loek van Alphen, Albert D.M.E O

Journal:

Year:

2000

Language:

english

File:

PDF, 785 KB

english, 2000

34

Reduction of animal use in human vaccine quality control: opportunities and problems

Bernard Metz, Coenraad.F.M Hendriksen, Wim Jiskoot, Gideon F.A Kersten

Journal:

Year:

2002

Language:

english

File:

PDF, 497 KB

english, 2002

35

Liposomes and ISCOMs

Gideon F.A Kersten, Daan J.A Crommelin

Journal:

Year:

2003

Language:

english

File:

PDF, 243 KB

english, 2003

36

Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes

Carmen Arigita, Gideon F.A. Kersten, Ton Hazendonk, Wim E. Hennink, Daan J.A. Crommelin, Wim Jiskoot

Journal:

Year:

2003

Language:

english

File:

PDF, 194 KB

english, 2003

37

Longevity of neutralizing antibody levels in macaques vaccinated with Quil A-adjuvanted measles vaccine candidates

Koert J Stittelaar, Helma W Vos, Geert van Amerongen, Gideon F.A Kersten, Albert D.M.E Osterhaus, Rik L de Swart

Journal:

Year:

2002

Language:

english

File:

PDF, 69 KB

english, 2002

38

Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice

Inez M. van der Lubben, Gideon Kersten, Marjan M. Fretz, Coen Beuvery, J. Coos Verhoef, Hans E. Junginger

Journal:

Year:

2003

Language:

english

File:

PDF, 163 KB

english, 2003

39

Single shot with tetanus toxoid in biodegradable microspheres protects mice despite acid-induced denaturation of the antigen

Gideon F.A. Kersten, Dian Donders, Arnoud Akkermans, E.Coen Beuvery

Journal:

Year:

1996

Language:

english

File:

PDF, 728 KB

english, 1996

40

Antigenic and immunogenic properties of inactivated polio vaccine made from Sabin strains

Gideon Kersten, Ton Hazendonk, Coen Beuvery

Journal:

Year:

1999

Language:

english

File:

PDF, 910 KB

english, 1999

41

Immunogenicity of various presentation forms of PorA outer membrane protein of Neisseria meningitidis in mice

Carla C.A.M Peeters, Ivo J.T.M Claassen, Margje Schuller, Gideon F.A Kersten, Eileene M Rouppe van der Voort, Jan T Poolman

Journal:

Year:

1999

Language:

english

File:

PDF, 213 KB

english, 1999

42

Characterization of Diphtheria Toxoid

GIDEON KERSTEN, WIM JISKOOT, TON HAZENDONK, ARJEN SPIEKSTRA, JANNY WESTDIJK, COEN BEUVERY

Journal:

Journal of Pharmacy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 77 KB

english, 1999

43

Structural perturbation of diphtheria toxoid upon adsorption to aluminium hydroxide adjuvant

Marie Régnier, Bernard Metz, Wichard Tilstra, Coenraad Hendriksen, Wim Jiskoot, Willem Norde, Gideon Kersten

Journal:

Year:

2012

Language:

english

File:

PDF, 606 KB

english, 2012

44

Quality-control issues and approaches in vaccine development

Metz, Bernard, van den Dobbelsteen, Germie, van Els, Cécile, van der Gun, Johan, Levels, Lonneke, van der Pol, Leo, Rots, Nynke, Kersten, Gideon

Journal:

Expert Review of Vaccines

Year:

2009

Language:

english

File:

PDF, 624 KB

english, 2009

45

Preparation and characterization of liposomes with incorporated Neisseria gonorrhoeae protein ib and amphiphilic adjuvants

Frans van Dalen, Gideon Kersten, Tom Teerlink, E.Coen Beuvery, Daan J.A. Crommelin

Journal:

Journal of Controlled Release

Year:

1988

Language:

english

File:

PDF, 1022 KB

english, 1988

46

Pulmonary Vaccine Delivery: A Realistic Approach?

Tonnis, Wouter F., Kersten, Gideon F., Frijlink, Henderik W., Hinrichs, Wouter L.J., de Boer, Anne H., Amorij, Jean-Pierre

Journal:

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Year:

2012

Language:

english

File:

PDF, 217 KB

english, 2012

47

Physicochemical and immunochemical assays for monitoring consistent production of tetanus toxoid

Metz, Bernard, Tilstra, Wichard, van der Put, Robert, Spruit, Nanda, van den IJssel, Jan, Robert, Jolanda, Hendriksen, Coenraad, Kersten, Gideon

Journal:

Year:

2013

Language:

english

File:

PDF, 515 KB

english, 2013

48

Development of Thermostable Lyophilized Inactivated Polio Vaccine

Kraan, Heleen, van Herpen, Paul, Kersten, Gideon, Amorij, Jean-Pierre

Journal:

Pharmaceutical Research

Year:

2014

Language:

english

File:

PDF, 3.01 MB

english, 2014

49

Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains

Westdijk, Janny, Koedam, Patrick, Barro, Mario, Steil, Benjamin P., Collin, Nicolas, Vedvick, Thomas S., Bakker, Wilfried A.M., van der Ley, Peter, Kersten, Gideon

Journal:

Year:

2013

Language:

english

File:

PDF, 603 KB

english, 2013

50

Identification of Formaldehyde-Induced Modifications in Proteins: Reactions with Insulin

Metz, Bernard, Kersten, Gideon F. A., Baart, Gino J. E., de Jong, Ad, Meiring, Hugo, ten Hove, Jan, van Steenbergen, Mies J., Hennink, Wim E., Crommelin, Daan J. A., Jiskoot, Wim

Journal:

Bioconjugate Chemistry

Year:

2006

Language:

english

File:

PDF, 110 KB

english, 2006